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SHODEX: Analyse 2-Deoxy-D-glucose (2-DG) with VG-50 4E

news | 22 July 2021
Tag: india shodex

As stated in BBC News (7 May 2021), India has begun distributing a new locally developed drug to treat Covid-19 symptoms.
Authorities have approved 2-DG and it is to be first used in hospitals across the capital, Delhi. According to a government statement, it "will be of immense benefit to the people suffering" from Covid-19.

2-DG or 2-Deoxy-D-glucose is a glucose molecule which has the 2-hydroxyl group replaced by hydrogen, and it is not metabolized by glycolysis. D-Glucal is the starting material for the synthesizing of 2-Deoxy-D-glucose. The separation of 2-Deoxy-D-glucose, D-Glucal and glucose was made by Shodex HILICpak VG-50 4E column which is a polymer-based amino column.

Sample : 10 µL
0.15 %(w/v) each in H2O/CH3CN=5/5
1. D-Glucal
2. 2-Deoxy-D-glucose
3. Glucose

Column : Shodex HILICpak VG-50 4E (4.6 mm I.D. x 250 mm)
Eluent : H2O/CH3CN=12/88
Flow rate : 1.0 mL/min
Detector : RI
Column temp. : 40 ℃

Source – (2021, May 7). India rolls out new local Covid drug after emergency approval. BBC News. https://www.bbc.com/news/world-asia-india-57139919 

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