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SHODEX Chromato News June 2022

news | 14 June 2022
Tag: chromatonews shodex

NEW! Technical Article No. 20

SEC Multi-Faceted Analysis of Exosome (EV) Combination of UV, Florescence, and Light Scattering Detectors

Exosome, an extracellular vesicle (EV), is responsible for transmitting various information and substances in living organisms. EVs are receiving great interests in the fields of new modality, because of their potential uses as highly sensitive diagnostic markers and therapeutic applications. Their transmission and target specific characteristics make them potentially significant in the treatment of various diseases. EVs have unique common physical and physiological properties including their sizes and surface antigens. However, their complex cell generation processes create diversities in the properties and encapsulated substances. Thus, they are often treated as mixtures of nano vehicles with certain variations. Therefore, the manufacturing of EV as a biopharmaceutical via bioprocessing requires development of production and evaluation methods that ensures consistent reproduction of EVs with the same characteristics throughout basic research, proof of concept, all clinical trial stages and actual production for clinical use. In addition, it is also important to control impurities generated during the production procedures. Those impurities include cell-originated components with which also have diversities.

Shodex offers hydrophilic aqueous polymer-base SEC columns that are suitable for analyzing various biological components. Shodex SEC columns with various pore sizes cover a wide molecular weight range, even the large nanoscale objects including EVs. Especially, SB-806 HQ with its sufficient pore size holds and separates EV-class nanoscale objects (50-200nm). Combined with a variety of detectors, this is a useful comprehensive analysis tool for a complex bio-nano compounds preparation process. This technical article introduces an example of multifaceted analysis and monitoring of an EV sample purification process using a SEC column, Shodex OHpak SB-806 HQ, with 3 different detectors.

EV Samples at each purification step:
✓ cell cuture supernatant,
✓ concentrate,
✓ purified product.

Click here to read the full PDF version.

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Showa Denko Starts Shipment of Newly Developed HD Media for Record-breaking 26TB Near-line HDD

news | 10 June 2022
Tag: Other

Showa Denko K.K. (SDK) (TOKYO: 4004) has started shipment of newly developed 3.5-inch hard disk media (HD media) to be used in 26 terabyte (TB) hard disk drive (HDD), which has the largest storage capacity the HDD industry has ever produced*1.

The new HD media support energy-assisted magnetic recording*2 and shingled magnetic recording*3 (SMR). This time, by introducing Showa Denko Group’s latest magnetic layer design and technology to produce fine crystals of magnetic substance on the surface of aluminum platter, we successfully developed HD media which have storage capacity of 2.6TB per platter, the largest one in the industry. Thus, the new HD media have pioneered the age of HD media designed for high-density magnetic recording beyond 1TB/in2, and we successfully combined technology to produce fine crystals of magnetic substance with technology to improve rewrite-cycle endurance on the surface of HD media, while maintaining compatibility with shingled magnetic recording (SMR). We will accelerate development of new HD media further, and aim to realize near-line HDD having storage capacity of more than 30TB by the end of 2023.

Due to the spread of cloud-computing service and increase in video content, data centers need HDDs with larger storage capacity. In the field of HD media, which are key part of HDDs and affect their storage capacities, the Showa Denko Group has been putting topflight products in the world onto the market before others. As the largest independent HD media supplier, the Showa Denko Group will continue contributing to the increases in storage capacities of HDDs in accordance with its motto of “Best in Class,” thereby supporting expansion of data economy.

*1: As of May 9, 2022
*2: Energy-assisted magnetic recording is a technology to record data on the surface of HD media with density higher than those achieved through conventional recording technologies, by pouring energy into magnetic substances which have high coercivity and assisting reversal of magnetization.
*3: Shingled magnetic recording is a technology to record data on the surface of HD media with high density by piling up a part of magnetic layers one another like singles.

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