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SHODEX Chromato News November 2021

news | 14 November 2021
Tag: chromatonews shodex

NEW! Technical Article No. 14

Analysis of Functional Ingredients in Dietary Supplements

In Japan, since April 2015, the nation started the “Foods with Functional Claims (FFC)” system to help general consumers obtain correct information and wisely select foods. A FFC product package clearly shows that it is a FFC product and describes its claimed functionalities. The product producers obtain the FFC by submitting the necessary documents to the Consumer Affairs Agency. The submission does not require any national examination to prove ingredient’s safety nor functionality. FFC is approved, as long as the producer states the functionality of the food based on scientific evidences and be responsible for the statement. There are more than 2,000 submitted FFC, this number is now more than the approved FOSHU. It can be said that the FFC market is keep expanding.

In this application, we optimized analytical conditions for the analyses of functional food ingredients that are registered as functional food ingredients in the database and which are used in commercial dietary supplementPolymers contain various additives for the additional functionality and stabilization of the product. Analysis of such additives is important for the quality control purposes in the polymer production. Those additives are typically analyzed by liquid chromatography and gas chromatography after pretreating the sample by extraction and concentration. The treatment steps are often complex and time consuming. On the other hand, by using the gel permeation chromatography (GPC), a polymer sample dissolved in an appropriate solvent can directly be analyzed. It separates the additives from polymers, and thus a simple and rapid detection can be expected.

✓ unsaturated fatty acids (docosahexanenoic acid (DHA), eicosapentaenoic acid (EPA))
✓ amino acid (Theanine)
✓ choline derivative (L-α-Glycerylphosphorylcholine (α-GPC))
salacinol and kotalanol 
coenzyme Q10

Click here to read the full PDF version.

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SHODEX Chromato News October 2021

news | 14 October 2021
Tag: chromatonews shodex

New Application Data on Shodex.com

★ Analysis of Oligo-DNAs (VN-50 2D) >> Application Note

☆ Analysis of Maltodextrin (VN-50 4D) >> Application Note

★ Analysis of Hexavalent Chromium by Post-Column Absorptiometry (SI-50 4E) >> Application Note

☆ Separation of Fosfomycin and its thermal decomposition products (NH2P-50 4E) >> Application Note

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SHODEX Chromato News September 2021

news | 14 September 2021
Tag: chromatonews shodex

New Application Data on Shodex.com

★ Analysis of Urea, an Impurity in Fluorouracil Injection Proposed in USP-NF Pharmacopeial Forum (SB-802.5 HQ) >> Application Note

☆ Analysis of Enoxaparin Sodium (KW-803 + KW-802.5) >> Application Note

★ Analysis of Meglumine (YS-50) >> Application Note

☆ Analysis of Meglumine (NN-814) to replace NN-414 >> Application Note

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SHODEX Chromato News August 2021

news | 15 August 2021
Tag: chromatonews shodex

New Application Data on Shodex.com

★ Analysis of 2-Deoxy-D-glucose (VG-50 4E)(add 2-Glucal) >> Application Note

☆ Biodegradable Polymer (6) (Polylactic Acid) (KF-806M) >> Application Note

Citric Acid Analysis in Functional Beverage (KC-811) >> Application Note

Carotene Analysis in Carrot Juice (C18U 2D) >> Application Note

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SHODEX Chromato News July 2021

news | 14 July 2021
Tag: chromatonews shodex

New Application Data on Shodex.com

Epoxy Resin (6) (Comparison of HK-402 and KF-802.5) >> Application Note

Epoxy Resin (7) ( Effects of Flow Rate for HK-402) >> Application Note

★ SEC/MALS Analysis of Exosome (SB-806 HQ) >> Application Note

Steviol Purity Test of Purified Stevia Extracts According to Japanese Pharmaceutical Excipients Method (C18M 4E) >> Application Note

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SHODEX Chromato News June 2021

news | 15 June 2021
Tag: chromatonews shodex

NEW! Technical Article No. 13

GPC/MS Analysis of Polymer Additives

Polymers contain various additives for the additional functionality and stabilization of the product. Analysis of such additives is important for the quality control purposes in the polymer production. Those additives are typically analyzed by liquid chromatography and gas chromatography after pretreating the sample by extraction and concentration. The treatment steps are often complex and time consuming. On the other hand, by using the gel permeation chromatography (GPC), a polymer sample dissolved in an appropriate solvent can directly be analyzed. It separates the additives from polymers, and thus a simple and rapid detection can be expected.

Shodex™ Technical Article No. 8: “Ultra-Rapid Analysis of High Molecular Weight Compounds Using SEC Mode” summarized the ultra-rapid analysis of high molecular weight compounds using Shodex™ GPC HK-400 series columns, which are packed with uniformly controlled 3- or 3.5-µm styrene divinylbenzene copolymers. This article introduces the rapid, highly sensitive, and highly selective applications analyzing various polymer additives using HK-400 series columns with THF eluent and an MS detector.

✓ phenolic antioxidants (Irganox 1010, Irganox 1076)
✓ hindered amine light stabilizer/HALS (ADK STAB LA-68).

Click here to read the full PDF version.

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SHODEX Chromato News May 2021

news | 15 May 2021
Tag: chromatonews shodex

NEW! Technical Article No. 12

Simultaneous LC/MS Analyses of Phosphorylated Saccharides

Phosphorylated saccharides take the important role as intermediates in various metabolic pathways of animals. For example, during glycolysis process, glucose is first converted to glucose-6-phosphate, then to other phosphorylated saccharides (such as fructose-6-phosphate and fructose-1,6-bisphosphate) and finally to pyruvate to produce ATP, the energy source of cell processing. Through glycogenolysis process, glucose-1-phosphate is produced from breakdown process of glycogen branches. In this process, glucose-6-phosphate is also produced as an isomer, and the product goes through a glycolysis process via different pathway. High sensitive analysis of phosphorylated saccharides in vivo is important for understanding the biological phenomena and early detection and treatment of the related diseases. One such case is glycogenosis, which stores abnormal amounts of glycogen in the body, and is possibly related to genetic glycogen enzymes deficiencies. Newborn glucose-6- phosphate concentration monitoring is considered an effective tool for the early detection of the disease.

In this application, we used a combination of Shodex™ HILICpak™ columns and LC/MS for simultaneous and high sensitive analysis of various phosphorylated saccharides without the use of ion-pair reagent nor derivatization.

✓ Phosphorylated Saccharides Using HILICpak™ VT-50 2D (glucose-1-phosphate (G1P), glucose-6-phosphate (G6P), fructose-1-phosphate (F1P), fructose-6-phosphate (F6P), fructose-1,6-bisphosphate (F1,6bP), and uridine diphosphate glucose (UDP-Glc));
✓ Phosphorylated Saccharides Using HILICpak™ VG-50 2D (fructose, glucose, G1P, G6P, UDP-Glc, and F1,6bP)

Click here to read the full PDF version.

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SHODEX Chromato News April 2021

news | 15 April 2021
Tag: chromatonews shodex

NEW! Technical Article No. 11

HPLC Analysis of Antidiabetic Drugs

Drugs, including antidiabetic drugs, with different targets have various chemical structures. This makes it difficult for an HPLC method to simultaneously analyze all antidiabetic drugs which may contain peptides, sugars, and lowmolecular weight compounds of different properties. Thus, analysis of each drug requires a specific method with an appropriate column and optimized analytical conditions. This technical article introduces application data for the analysis of four antidiabetic drugs using Shodex™ columns.

✓ Oral Antidiabetic Drug (Metformin);
Insulin
Liraglutide; and
Exenatide

Click here to read the full PDF version.

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SHODEX Chromato News March 2021

news | 15 March 2021
Tag: chromatonews indonesia shodex thailand

New Application Data on Shodex.com

★ Analysis of Thymosin α1 (KW-802.5) >> Application Note 

☆ Analysis of GABA Supplement (NH2P-50 4E) >> Application Note 

★ SEC Analysis of Latex Particles (KW405-4F) >> Application Note 

☆ Effects of Organic Solvent Concentration on HILIC Mode (NH2P-50 4B) >> Application Note 

★ Effects of Eluent pH on HILIC Mode (VG-50 2D) >> Application Note

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SHODEX Chromato News February 2021

news | 15 February 2021
Tag: chromatonews shodex

New Application Data on Shodex.com

★ Analysis of Zinc Sulfate Compounded Injection According to USP-NF Method (YK-421) >> Application Note

☆ Analysis of Potassium Bicarbonate and Potassium Chloride Effervescent Tablets for Oral Solution Proposed in USP-NF Pharmacopeial Forum (YK-421) >> Application Note

★ Analysis of Potassium and Sodium Bicarbonates and Citric Acid Effervescent Tablets for Oral Solution Proposed in USP-NF Pharmacopeial Forum (YK-421)  >> Application Note

☆ Analysis of Betadex Sulfobutyl Ether Sodium According to USP-NF Method (SB-803 HQ) >> Application Note

★ Analysis of Sucrose Proposed in USP-NF Pharmacopeial Forum (SC1011-7F) >> Application Note

☆ Analysis of Propylene Glycol Monocaprylate According to USP-NF Method (KF-801) >> Application Note

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SHODEX Chromato News January 2021

news | 20 January 2021
Tag: chromatonews shodex

New Application Data on Shodex.com

★ Analysis of Lactoferrin Supplement (C4P-50 4D)
☆ Analysis of Lactoferrin Concentrate According to Analytical Methods of Food Additives in Foods (C4P-50 4D)
★ Analysis of Erythrose and Threose (SC1011)
☆ Analysis of Erythrose and Erythritol (VG-50 4E)
★ Analysis of α-Linolenic Acid in Edible Blended Oil (ODP-50 4D)
☆ Analysis of Pamidronate Disodium According to USP-NF Method (IC I-524A)
★ Analysis of Sodium Risedronate (IC I-524A)
☆ Analysis of Sodium Ibandronate (IC I-524A)
★ Analysis of Zoledronic Acid (IC I-524A)

Click here to read the full PDF version >>> Chromato News JAN 2021 – English

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SHODEX Chromato News November 2020

news | 30 November 2020
Tag: chromatonews shodex

New Application Data on Shodex.com

★ Analysis of Oligomers in Omega-3 Free Fatty Acids According to USP-NF (KF-802.5 + KF-802 + KF801)
☆ Analysis of Calcium Acetate Capsules According to USP-NF (YK-421)
★ Analysis of Chloride According to the Japanese Testing Methods for Fertilizers (NI-424)
☆ Analysis of Chloride According to the Japanese Testing Methods for Fertilizers (SI-52 4E)
★ Analysis of Levocarnitine (NH2P-50 4E)
☆ Rapid Analysis of Malto-oligosaccharides, Organic Acids, and Ethanol (SH1011 8C)
★ Analysis of Inositol According to Japanese Pharmaceutical Excipients 2018 (KS-801)

Click here to read the full PDF version >>> Chromato News NOV 2020 – English

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SHODEX Chromato News October 2020

news | 21 October 2020
Tag: chromatonews shodex

Analysis of Functional Sugars in Foods Using HILIC Mode.

Recently, the effects of functional sugars in foods are gaining scientists’ interests, and thus their analytical methods are called for. This article will demonstrate the effectiveness of Shodex™ HILICpak™ VG-50 4E with its HILIC mode for the analysis of various functional sugars in foods. The eluent typically used in HILIC mode is a mixture of water and acetonitrile. And for some applications, the separation efficiency of the VG-50 4E can be improved by using a mixture containing water, acetonitrile, and methanol. We also proved the effectiveness of the developed method for analyzing functional sugars in real food products.

Click here to read the full PDF version >>> Chromato News OCT 2020 – English

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SHODEX Chromato News August 2020

news | 01 August 2020
Tag: chromatonews shodex

New Application Data on Shodex.com!

★ LC/MS Analysis of Glyphosate and Glufosinate with (VT-50 2D)
☆ Charge Variant Analysis of Trastuzumab with (SP-FT 4A)
★ Charge Variant Analysis of Cetuximab with (SP-FT 4A)
☆ Charge Variant Analysis of Cetuximab (2) with (SP-FT 4A)
★ Speciation of Chromium by LC/ICP-MS (2) with (VC-50 2D)

Click here to read the full PDF version >>> Chromato News AUG 2020 – English

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SHODEX Chromato News July 2020

news | 01 July 2020
Tag: chromatonews shodex

Ultra-Rapid Analysis of Proteins by Cation Exchange Chromatography

High Performance Liquid Chromatography (HPLC) takes an important role in the pharmaceutical and biotech industry for the analysis of biological components such as proteins, peptides, and nucleic acids. The Shodex™ IEC SP-FT 4A shortens the analysis time to one-third of previous IEC SP-420N, while the column remains to provide sharp peak shapes. Dimensions are 4.6 mm inner diameter and 10 mm length, and housing made of PEEK.

Application data includes:

  1. Ovalbumin
  2. Trypsinogen
  3. Ribonuclease A
  4. Cytochrome C
  5. Lysozyme
  6. α-Chymotrypsinogen A
  7. AFSC Hemoglobin Control, normal hemoglobins,
    HbF(F) and HbA(A), abnormal hemoglobins, HbS(S) and HbC(C)
  8. HbA1c or glycohemoglobin

Click here to read the full PDF version >>> Chromato News JUL 2020 – English

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SHODEX Chromato News June 2020

news | 01 June 2020
Tag: chromatonews shodex

New Application Data on Shodex.com!

★ Analysis of Allantoin in a Commercial Disinfectant (VG-50 4E)
☆ LC/MS/MS Analysis of Glyphosate and Glufosinate (VT-50 2D)
★ SEC Analysis of Filgrastim (KW-803)
☆ Analysis of Ethylcellulose Dispersion Type B According to USP-NF (KF-802)
★ Analysis of Coenzyme Q10 in a Dietary Supplement (C18P 4D)

Click here to read the full PDF version >>> Chromato News JUN 2020 – English

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SHODEX Chromato News February 2020

news | 01 February 2020
Tag: chromatonews shodex

New Application Data on Shodex.com!

★ Quantification of N-Methylpyrrolidine in Cefepime for Injection According to USP Method (YK-421)
☆ Quantification of Alendronate Sodium Hydrate According to JP Method (DS-413)
★ Analysis of Phosphorothioated Oligo DNA (VN-50 2D)
☆ SEC Analysis of PEG-Asparaginase (SB-806 HQ)

Click here to read the full PDF version >>> Chromato News FEB 2020 – English

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SHODEX Chromato News November 2019

news | 01 November 2019
Tag: chromatonews shodex

New Anion Analysis Column using KOH Eluent: Shodex IC SI-36 4D

★ Analysis of Anions (SI-36 4D)
☆ Effects of Potassium Hydroxide Concentration on Retention Time (1) and (2) (SI-36 4D)
★ Effects of Temperature on Retention Time (SI-36 4D)

New Application Data on Shodex.com!

★ Analysis of Unsaturated Fatty Acids in Supplements (ODP-50 4D)
☆ Analysis of Polysorbate 80 in Antibody Drugs (ODP2 HP-4D)
★ Drug Antibody Ratio Analysis of Antibody-Drug Conjugate (ODP2 HP-4B)
☆ Analysis of Somatropin According to EP Method (LW-803)

Click here to read the full PDF version >>> Chromato News NOV 2019 – English

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SHODEX Chromato News September 2019

news | 01 September 2019
Tag: chromatonews shodex

New Application Data on Shodex.com!

★ Analysis of Theanine in Supplement (NH2P-50 4E)
☆ Analysis of Fructooligosaccharides in Accordance to the Food System for Specified Health Use (VG-50 4E)
Deoxyribonucleotide (WA-624)

Tips
☆ How to maximize the life of Shodex SUGAR columns when analyzing in high temperature

Click here to read the full PDF version >>> Chromato News SEP 2019 – English

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SHODEX Chromato News August 2019

news | 01 August 2019
Tag: chromatonews shodex

New Application Data on Shodex.com!

Pullulan Standard Kit P-82 is now available for Indonesia
★ Separation of Water-Soluble Vitamin and Sulfite (KC-811)
Laminarin (SB-806M HQ)
★ Analysis of Epinephrine According to USP (In-Process Revision) (CDBS-453)
☆ Chiral Separation of Norepinephrine (CDBS-453)
Ginsenoside (Carrot Saponin) (NH2P-50 4E)
☆ LC/MS analysis of Polysorbate 20 in Antibody Drug Complex Preparation (ODP2 HP-2B)

Click here to read the full PDF version >>> Chromato News AUG 2019 – English

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SHODEX Chromato News May 2019

news | 01 May 2019
Tag: chromatonews shodex

Wishing You A Blessed Ramadan
May the spirit of Ramadan show us the way to peace and harmony.

LC/MS Analysis of Glyphosate and Its Related Compounds Using Shodex™ HILICpakTM VT-50 2D

Organophosphate herbicides are globally used non-selective weed killer. Due to concerns on their toxicity to humans, monitoring their concentrations in environment and foods are important. In this edition, we show the analysis of 6 organophosphate herbicides: glyphosate and its metabolite, aminomethylphosphonic acid (AMPA), and glufosinate and its metabolites, 3-methylphosphinicopropionic acid (MPPA), ethephon, and fosetyl.

Click here to read the full PDF version >>> Chromato News MAY 2019 – English

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SHODEX Chromato News April 2019

news | 01 April 2019
Tag: chromatonews shodex

NEW! Technical Article No. 7

Analysis of Various Oligosaccharides by HILIC Mode

It is known that oligosaccharides are utilized by gut bacteria inside the animal bodies, providing digestive health benefits. HILIC mode are commonly used these days because it provides better separation for oligomers than SEC mode. Shodex™ HILICpak™ VN-50 series columns are specifically developed for the separation of high-molecular weight oligosaccharides that were difficult to be analyzed by previously available HILIC columns.

✓ Nonionic oligosaccharides such as dextrin, N-acetylchitooligosaccharides (polymer of N-acetylglucosamine) and xylooligosaccharides;
✓ Cationic oligosaccharides, chitosan-oligosaccharides (polymer of glucosamine); and
✓ Anionic oligosaccharides, oligogalacturonic acids

Click here to read the full PDF version >>> Chromato News APR 2019 – English

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SHODEX Chromato News March 2019

news | 01 March 2019
Tag: chromatonews shodex

New Applications Data on Shodex.com Website!

Methacrylic Acid Copolymer (KF-806M)
☆ Chiral Separation of Asparagine (CRX-853)
★ Chiral Separation of Proline (CRX-853)
☆ Chiral Separation of Tryptophan (CRX-853)
★ SEC Analysis of Liraglutide Formulation (KW-802.5)
☆ Analysis of Oligogalacturonic Acids (VN-50 4D)
★ LC/MS Analysis of Hexamethylenetetramine (VC-50 2D)
☆ Analysis of Sorbitol According to USP Method (SP0810 8C)
★ Analysis of Maltitol According to USP (SP0810 8C)
☆ Comparison of Sensitivity of NH2P Polymer-based Column and Silica-based Amino Column with ELSD

Click here to read the full PDF version >>> Chromato News MAR 2019 – English

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SHODEX Chromato News February 2019

news | 01 February 2019
Tag: chromatonews shodex

Shodex Singapore Team wishes You
🏮 Happy Lunar New Year! 恭喜发财🏮

NEW! Technical Article No. 6

Simultaneous Analysis of Ten Water-Soluble Vitamins Using a Polymer-Based Reversed Phase Column Shodex™ RSpak DE-413L

Methods using microbiological assays, absorption spectrophotometry, and HPLC are laborsome and time consuming process. Use of ODS column with an addition of ion-pair reagent tends to remain on the column and the flow-lines, results in increased background level and lowers the sensitivity. In this application, we aimed to develop a simple method to simultaneously analyze various water-soluble vitamins. We used Shodex™ RSpak DE-413L, a polymer-based reversed phase column, without a use of ion-pair reagent.

Click here to read the full PDF version >>> Chromato News FEB 2019 – English

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SHODEX Chromato News January 2019

news | 01 January 2019
Tag: chromatonews shodex

NEW! Technical Article No. 5

LC/MS Analysis of Various Low-Molecular Weight Cationic Compounds Using a Polymer-Based Carboxyl HILIC Column Shodex™ HILICpak™ VC-50 2D

Most low-molecular weight cationic compounds are hydrophilic and hardly retained under reversed phase mode. To compromise the problem, pre-column derivatization and ion-pair chromatography techniques are often used. VC-50 2D column provides a highly sensitive analysis of various low-molecular weight cationic compounds, while requiring simpler analytical conditions than the methods previously available.

Click here to read the full PDF version >>> Chromato News JAN 2019 – English

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SHODEX Chromato News December 2018

news | 01 December 2018
Tag: chromatonews shodex

Shodex Singapore Team wishing you and your family Happy Holidays

NEW! Technical Article No. 4

LC/MS Analysis of Oligonucleotides Using a Polymer-Based Diol Column
– Shodex™ HILICpak™ VN-50 2D

The oligonucleotide therapeutics have high expectations for the usage in not only treating genetic and metabolic disorders, but as for anti-cancer drugs and vaccines of various diseases. Shodex™ HILICpak™ VN-50 have been successfully measuring various oligosaccharides. And it is found to be also effective for the analysis of oligonucleotides.

Click here to read the full PDF version >>> Chromato News DEC 2018 – English

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SHODEX Chromato News October 2018

news | 01 October 2018
Tag: chromatonews shodex

New Application Data on Shodex.com Website!

FAST and ECONOMICAL Analysis

☆ LC/MS Analysis of Streptomycins (VC-50 2D)
★ LC/MS/MS Analysis of Citicoline (VT-50 2D)
☆ LC/MS Analysis of Low Molecular Weight Peptides (VC-50 2D)
Epoxy Resin (4) (Comparison of HK-404L and HK-404L + HK-401)
Biodegradable Polymer (4) (Polylactic Acid) (HK-404L)

Click here to read the full PDF version >>> Chromato News OCT 2018 – English

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SHODEX Chromato News September 2018

news | 01 September 2018
Tag: chromatonews shodex

NEW! Technical Article No. 3

LC/MS Analysis of Various Hydrophilic Compounds Using a Polymer-Based Amino Column
– Shodex™ HILICpak™ VG-50 2D

High polar compounds in pharmaceutical and food products are hardly retained under Reversed Phased mode, and to compromise the problem, pre-column derivatization or addition of ion-pair reagent to the eluent are often applied. Drawbacks are the complicated and time taking process of the derivatization and increase of background level caused by the ion-pair reagent residues on the column and the flow-lines.

However, Shodex™ HILICpack™ VG-50 2D, provides the solution with its advantageous analytical features when used under alkaline conditions. LC/MS with ammonia water/acetonitrile gradient elution is effective for good separation and high sensitivity analysis of various hydrophilic compounds. It can analyse saccharides, organic acids, and amino acid simultaneously, and able to monitor caffeine and water-soluble vitamins simultaneously. These can be achieved without using pre-column derivatization nor addition of ion-pairing reagent.

Click here to read the full PDF version >>> Chromato News SEP 2018 – English

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SHODEX Chromato News August 2018

news | 01 August 2018
Tag: chromatonews shodex

New Application Data on Shodex.com Website!

☆ Separation of Taurine and Inositol (NH2P-50 4E)
★ Comparison of Analysis of Glucosamine Hydrochloride between Polymer-based Amino Columns vs Silica-based Amino Columns
Fucoidan (SB-806M HQ)
★ Analysis of Cyclodextrins According to Japan’s Specifications and Standards for Food Additives Method (KS-802)
Galactooligosaccharides (2) (KS-801, NH2P-50 4E)
Xylooligosaccharides (3) (SH1011)
Xylooligosaccharides (2) (VN-50 4D)
★ Chitosan-Oligosaccharides (Chitooligosaccharides) (3) (VN-50 4D)
N-Acetylchitooligosaccharides (2) (VN-50 4D)

Click here to read the full PDF version >>> Chromato News AUG 2018 – English

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SHODEX Chromato News June 2018

news | 01 June 2018
Tag: chromatonews shodex

Introducing the New PROTEIN LW-403 4D!

Analyze proteins more rapidly and more economically with the newly optimized Shodex™ PROTEIN column: LW-403 4D.

DURABILITY Tested by Number of Sample Injections (LW-403 4D)
★ Calibration Curve for LW-403 4D (Proteins)
2X FASTER SEC Separation of IgG than Conventional Protein Column
2X FASTER SEC Separation of Standard Proteins than Conventional Protein Column

Click here to read the full PDF version >>> Chromato News JUN 2018 – English

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SHODEX Chromato News May 2018

news | 01 May 2018
Tag: chromatonews shodex

☪️RAMADAN MUBARAK – HAPPY RAMADAN ☪️
May the spirit of Ramadan show the way to peace and harmony.

4 New Application Data on Shodex.com Website!

☆ Assay of Polyethylene Glycol 3350 According to USP Method (SB-802.5 HQ)
★ Measurement of Apparent Weight-Average Molecular Weight and Polydispersity of Polyethylene Glycol 3350 According to USP Method (SB-803 HQ)
Colominic Acid (SB-804 HQ)
Hydroxypropyl-β-cyclodextrin (SB-802.5 HQ)
☆ Effects of Temperature on Retention Time (SI-35 2B)
★ Calibration Curves (SI-35 2B)

Click here to read the full PDF version >>> Chromato News MAY 2018 – English

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SHODEX Chromato News April 2018

news | 01 April 2018
Tag: chromatonews shodex

LET’S GET WORKS DONE FASTER 😉
In this month’s newsletter, we introduce 2 new polymer-based columns for faster analysis, helping you & your team save time in your work and achieving better productivity.

Firstly, we have our new SUGAR SP0810 8C column, which is an 8.0 x 100mm, USP L34 equivalent column that is suitable for USP Sorbitol as well as Fast carbohydrates analysis. It composes of strong cation-exchange resin consisting of sulfonated cross-linked styrene-divinylbenzene copolymer in the lead (Pb) form, and allows for the analysis of sucrose, glucose, galactose, fructose within 5 minutes due to the short 100mm length. If you are looking for a short USP L34 column, please feel free to contact us.

Next up, we have our IEC SP-FT 4A column, a cation exchange column for UHPLC modified with sulfopropyl groups on a non-porous polymethacrylate base material, for the ultra-rapid analysis of proteins and the like. Five standard proteins can be separated within 50 seconds under high flow rate condition of 3.0 mL / min.

Click here to read the full PDF version >>> Chromato News APR 2018 – English

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SHODEX Chromato News March 2018

news | 01 March 2018
Tag: chromatonews shodex

New Applications Data on Shodex.com Website!

☆ Analysis of Various Tween Type Surfactants (GF-210 HQ)
★LC/MS Analysis of Analysis of Tween Type Surfactants in IgG (ODP2 HP-2D)
☆ Standard Proteins (28) (Comparison of SP-FT 4A and SP-420N)
★ Effects of Flow Rate for Protein Analysis (SP-FT 4A)
☆ Ultra-rapid Analysis of Standard Proteins (SP-FT 4A)
★ Ultra-rapid Analysis of Hemoglobin A, F, S and C (SP-FT 4A)
☆ Analysis of Tagatose According to USP Method (SC1011)
★ Analysis of 2-Aminobenzoic Acid Labeled Glucose Homopolymer (NH2P-50 4E)
☆ Polyamide (12) Nylon 6/9 (HK-HFIP404L)
★ Polyamide (13) Nylon 11 (HK-HFIP404L)
☆ Rapid Analysis of Anion Standards (SI-35 2B)
★ Analysis of Ionic Liquid (YS-50)
☆ LC/MS Analysis of Ionic Liquid (VC-50 2D)

Click here to read the full PDF version >>> Chromato News MAR 2018 – English

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SHODEX Chromato News February 2018

news | 01 February 2018
Tag: chromatonews shodex

Shodex Singapore Team wishes You
恭喜发财 🏮 Happy Lunar New Year! 🏮

Analysis method of Aggregates and Additives in Antibody Drugs

Antibody drugs are important potent therapeutic drugs. Because of their highly specific targeting capacity to the cancer cells, it can cause less side effects. However, it is known that they may aggregate to form dimers and other larger aggregates during manufacturing process and/or during storage period. Therefore, monitoring of such aggregates are important for quality control (QC) purposes. Shodex™ PROTEIN LW-803 demonstrated its superior separation capability for IgG monomers and its aggregates. While, Shodex™ ODP2 HP-2D proved its separation capability of analyzing non-ionic surfactant, Tween, in the presence of IgG and NaCl, without the necessity of deproteinization nor desalting sample pretreatment.

Click here to read the full PDF version >>> Chromato News FEB 2018- English

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SHODEX Chromato News January 2018

news | 01 January 2018
Tag: chromatonews shodex

Shodex Singapore Team wishes You a Prosperous and Joyful year ahead.
Happy New Year 2018!

Q: SHODEX makes Polymer-based HPLC columns, are they listed in Pharmacopeia-related Monographs? 【・_・?】

A: YES. The United States Pharmacopeia (USP), European Pharmacopeia (EP) and Japanese Pharmacopeia (JP) have established standard guidelines for analysis and are used widely by regulatory agencies and industries throughout the world to ensure products are of appropriate qualities. In this multi-page Special Edition, we will be bringing you a list of Shodex HPLC columns that may be suitable for analytical methods available in the above-mentioned Pharmacopeias, as well as examples of application data obtained with these specific types of columns. Examples include the analysis of Organic acids, Insulin Glargine, Mannitol, Dextrose and other sugars, Azithromycin, and more.

Click here to read the full PDF version >>> Chromato News JAN 2018- English

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SHODEX Chromato News November 2017

news | 01 November 2017
Tag: chromatonews shodex

6 New Application Data on Shodex.com Website!

★ Analysis of Choline and Acetylcholine (YS-50)
☆ LC/MS Analysis of Choline and Acetylcholine (VC-50 2D)
★ LC/MS/MS Analysis of Salacia Extract (1) (VC-50 2D)
☆ LC/MS/MS Analysis of Salacia Extract (2) (VC-50 2D)
★ LC/MS Analysis of Glucose and Gluconic Acid (VG-50 2D)
Biodegradable Polymer (3) (Polylactic Acid) (K-805L)
★ Comparison of Separation using HK-404L with

Click here to read the full PDF version >>> Chromato News NOV 2017 – English

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SHODEX Chromato News October 2017

news | 01 October 2017
Tag: chromatonews shodex

6 New Application Data on Shodex.com Website!

★ Monitoring Papain Digestion of Humanized Monoclonal IgG (LW-803)
☆ Analysis of High Molecular Impurities in Insulin Aspart According to Pharmacopeia (KW-802.5)
★ Analysis of Preservatives According to Analytical Methods of Food Additives in Foods (1) (C18P 4E)
☆ Analysis of Preservatives According to Analytical Methods of Food Additives in Foods (2) (C18P 4E)
★ SEC Analysis of LMW Heparin (1) (Dalteparin Sodium) (KW-803 + KW-802.5)
☆ SEC Analysis of LMW Heparin (2) (Parnaparin Sodium) (KW-803 + KW-802.5)
★ Calibration Curves for GF-HQ Series (THF Eluent: PS)
☆ Calibration Curves for KD-800 Series (DMF Eluent: PMMA)
★ Calibration Curves for UT-800 Series (ODCB Eluent: PS)
☆ Calibration Curves for HT-800 Series (ODCB Eluent: PS)
★ Calibration Curve for AT-806MS (ODCB Eluent: PS)
☆ Calibration Curve for LF-404 (HFIP Eluent: PMMA)

Click here to read the full PDF version >>> Chromato News OCT 2017 – English

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SHODEX Chromato News September 2017

news | 01 September 2017
Tag: chromatonews shodex

Showa Denko to Launch New Shodex Analytical Columns

Showa Denko (SDK) will start selling next month, five new types of Shoedx high-performance liquid chromatography (HPLC) columns, namely, GPC HK-401, GPC HK-405 and GPC HK-HFIP404L packed columns for gel permeation chromatography (GPC: size exclusion chromatography [SEC] using organic solvents), as well as OHpak LB-805 packed column for gel filtration chromatography (GFC: SEC using aqueous solvents) and IEC SP-FT 4A packed column for ion exchange chromatography.
The five new analytical columns SDK developed this time feature more rapid analysis and higher sensitivity, which has been desired by analytical column users. SDK will continue meeting our customers’ needs by developing columns which enhances accuracy of analysis of target materials in a certain range of molecular weight, as well as those which enable analysis of hardly-soluble polymers and rapid analysis which is desired by users in the fields of medicine manufacturing and biochemistry, even with general analyzers.
More information about the new products and application data will be included in future editions of Chromato News.
Please look forward to it!

New Application Data on Shodex.com Website!

Saccharides and Amino Acids (3) (KS-801)
☆ Analysis of Dextrose According to USP (SC1011)
★ Analysis of Ascorbic Acid Injection According to USP (DM-614)
☆ Analysis of Trehalose According to USP Method (KS-801)
★ Analysis of Lipoproteins in Serum (KW-804)
Polystyrene Standards (23) (HK-404L)
Poly(Methyl Methacrylate) (3) (HK-404L)
Poly(Butyl Methacrylate) (2) (HK-404L)
Styrene Butyl Methacrylate Copolymer (3) (HK-404L)
☆ LC/MS/MS Analysis of Ribavirin (VC-50 2D)
★ LC/MS Analysis of Iodide (VT-50 2D)
☆ LC/UV/MS Analysis of Oligo DNA (VN-50 2D)

Click here to read the full PDF version >>> Chromato News SEP 2017 – English

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